SAN FRANCISCO -- Less than four innings into San Francisco Giants right-hander Matt Cain's start Tuesday night, the Arizona Diamondbacks were on no-hit alert.

As soon as they put that behind them, the Diamondbacks did what they do best -- win in San Francisco.

Chris Owings' first-pitch double in the fifth inning ended Cain's no-hit bid, and the Diamondbacks went on to continue their recent dominance of the Giants in AT&T Park, getting a combined six-hit shutout from four pitchers en route to a 3-0 victory.

"Somebody had said something in the fourth inning," Owings said of Cain's early no-hit effort. "We'd had some real good at-bats. Once we got the one (hit), it went from there."

Owings' double triggered a three-run uprising that propelled the Diamondbacks to their eighth win in their past nine games in San Francisco.

"They like playing here," Diamondbacks manager Chip Hale said of his 7-8 club, which won its third in a row and fifth in eight outings on its current 10-game trip. "(The Giants) sell out every night, and their crowd is really into it. Our guys like that. They rise to the occasion."

Starter Robbie Ray (1-0) and relievers Andrew Chafin, Evan Marshall and Tyler Clippard teamed to stifle a Giants team that totaled 33 runs in its first five home games, including seven in a 9-7, 11-inning loss to Arizona in the series opener Monday.

Clippard overcame an inning-opening walk to pitch a scoreless ninth for his first save, completing the Diamondbacks' first shutout of the season.

Ray got the ball rolling with six shutout innings, striking out a career-best-tying eight. He allowed five hits and two walks but stranded three Giants in scoring position.

"Lights-out stuff tonight," Hale said. "His fastball was unhittable. That's the guy that excited us."

It was Ray's third consecutive quality start to open the season, and the sixth straight time he allowed two or fewer runs in a game, dating back to last season.

That stretch began with six shutout innings against the Los Angeles Dodgers in an 8-0 win last Sept. 22, leading to his first combined shutout. The bullpen helped make it two on Tuesday.

"I want to continue to build," said Ray, who was not happy with his two walks, which gave him 11 for the season. "I can build off the walks."

Cain (0-2) was even better than Ray for four innings, pitching around four walks, before the Diamondbacks got going in the fifth.

Owings put the rally in motion by lashing Cain's first pitch of the inning to the fence in left-center field for a double.

Ray sacrificed Owings to third, and Jean Segura produced the game's first run with a single.

Jake Lamb, who had two doubles and a home run in Arizona's win Monday, followed with an RBI triple to make it 2-0, then came home on Paul Goldschmidt's sacrifice fly.

"The stuff's there. I just didn't manage the inning right," Cain said. "I think we had the right idea of what we wanted to do. I just didn't execute some of the right pitches."

Subsequent two-out singles by David Peralta and Yasmani Tomas ended Cain's night, but the Diamondbacks did no further damage against four Giants relievers.

Owings had two of the Diamondbacks' eight hits.

Matt Duffy, who entered the game hitless in his past 13 at-bats, had two singles for the Giants, who were shut out for the first time this season.

The loss was the Giants' third in a row and sixth in their last seven games. They fell under .500 for the first time this season at 7-8.

Cain gave up just the three fifth-inning runs on five hits in his 4 2/3-inning effort. He walked four and struck out two.

His outing was similar to his previous start in Colorado, when he retired 12 of 13 batters through four innings, then got lit up for five hits -- including two doubles and a home run -- among the first six batters he faced in the fifth.

The Rockies scored nine runs in the inning, six off Cain, en route to an 11-6 win.

"He just lost his good command," Giants manager Bruce Bochy responded when asked if fatigue has been an issue for his veteran. "His pitches were going back over the middle. He lost it there, and we had to go get him."

NOTES: The Giants failed to score while RHP Matt Cain was on the mound for the third straight time this season and 48th time in his career. ... The Diamondbacks and Giants each had two representatives on the Pac-12's 30-member All-Century baseball team that was announced Tuesday. LHP Randy Johnson (USC, 1983-85) and manager Chip Hale (Arizona, 1984-87), who was picked as a third baseman, were members of the Diamondbacks' organization selected. Giants honored were RHP Tim Lincecum (Washington, 2004-06) and LF Barry Bonds (Arizona State, 1983-85). ... QB Jared Goff was scheduled to throw out the first pitch on "Cal Night" at AT&T Park, but the possible No. 1 pick in next week's NFL Draft was summoned to Los Angeles for an unscheduled trip earlier in the day. Cal coach Sonny Dykes made the ceremonial toss in relief of Goff. ... Both teams made pitching transactions before the game. The Diamondbacks optioned Monday's starting pitcher, RHP Archie Bradley, to Triple-A Reno and recalled RHP Silvino Bracho from Reno. The Giants promoted two pitchers -- LHP Steven Okert and RHP Mike Broadway -- from Triple-A Sacramento, replacing RHP George Kontos, who went on the 15-day disabled list with a strained flexor tendon in his right arm, and RHP Chris Heston, who was sent to Sacramento. Okert, making his major league debut, and Broadway both pitched in the game, combining for three shutout innings.